My screen has almost changed into negative look how do I change this on iPad 2

Perform a forced-restart of your iPad - as this will often resolve an isolated issue:

• On an iPad with a Home button: Press and hold the top button and the Home button at the same time. When the Apple logo appears, release both buttons.
• On other iPad models: Press and quickly release the volume up button, press and quickly release the volume down button, then press and hold the top button. When the Apple logo appears, release the button.

If the screen colours appear to be distorted or unnatural, you need to check some key Accessibility settings that are intended to compensate for specific colour-vision issues:

Settings > Accessibility > Display & Text Size

Ensure that all settings enclosed within the red box above are switched OFF/Disabled.