The Other category can be reduced, but requires caution in doing so (otherwise app data could be corrupted). Nonetheless, macOS already protects system critical files:
In macOS Catalina or later, there is a separate System category, and it should only take up 15-20 GB at most. That category would include core macOS files and everything that resides on the read-only system volume. The remaining "Other" category may include certain caches, but nothing that would be essential to macOS.
In macOS Mojave or earlier, the "System" and "Other" categories are unified into just "Other". Although the system files and user data reside in the same volume, System Integrity Protection prevents anyone (including the root superuser) from deleting or modifying critical macOS files. That protection can only be disabled from macOS Recovery, and only if explicitly requested from the command line.