Mac (Monterey) crashes repeatedly.

You are right.

Turns out the HUB on its own is sufficient to cause the panic on "wake from sleep".

Just the HUB, no other peripherals plugged into the HUB.

While "awake" everything works as expected.

This is a new problem with Monterey, as the HUB and peripherals worked under BigSur even during "wake from sleep".

system.log file contains these error messages, starting from no1, to 130

AMPDeviceDiscoveryAgent[499]: Entered:__thr_AMMuxedDeviceDisconnected, mux-device:129

AMPDeviceDiscoveryAgent[499]: Entered:_AMMuxedDeviceDisconnected, mux-device:130

AMPDeviceDiscoveryAgent[499]: Entered:_AMMuxedDeviceDisconnected, mux-device:128

AMPDeviceDiscoveryAgent[499]: Entered:__thr_AMMuxedDeviceDisconnected, mux-device:130

AMPDeviceDiscoveryAgent[499]: Entered:__thr_AMMuxedDeviceDisconnected, mux-device:128

Welcome to the Apple Support Communities.

I believe we need to proceed with an EtreCheck report. EtreCheck is a useful App to diagnose and identify issues, both hardware and software. It is trusted by many users. Please follow the steps outlined below:

1. Navigate to: https://etrecheck.com and get the free version of EtreCheckPro.
2. Download it. It is a free and trusted app. It is often recommended here on Apple Support Communities. 
3. Open EtreCheck, and before running the report, be sure to check “Allow full Drive Access” at the bottom of the EtreCheckPro window.
4. Run the report, and put it in a post, as seen here: https://discussions.apple.com/docs/DOC-250000211. We will then examine the report for issues in your Mac.

Jack

I have upgraded to Monterey 12.0.1 on a new M1 Desktop.

It also crashed "after wake" with a panic connected to AMMuxedDevice a USB HUB.

So I remove the device altogether, and the panic does not occur.

I replace the device and the panic recurs.

I suggest you remove all peripherals and USB HUBS, and only add your USB HUB when you are using the devices.

I have Scanner, Printer, BackupDisk and TV through my hubs.

Sadly no no more.

Hopefully Apple will fix this bug ASAP.

It did not occur with Big Sur.

Your issue may be any one of the following as you have found that the KPs cease after removing all of them.

• Your USB hub
• Any one of the external peripherals

The only way to narrow down what it is is to to use trial and error. In other words introduce each item 1 by 1 and test completely for each device until you find the culprit. You have to be slow and methodical and take good notes.

+1 please post an EtreCheck report.

The issue isn't Monterey, it is the hub. As hubs are relatively inexpensive I would simply replace it. Personally I prefer OWC (www.macsales.com) for accessories. The reason I do is they specialize in Macs and everything they sell has been tested. They also have great prices and excellent pre-and post sales service.

I agree that the HUB is causing my problems. I will get another.

YET

It used to work fine in BigSur, so it is an added feature of Monterey leading to this issue.

BUT

A peripheral causing a Kernel Panic is "bad".

The HUB should be "disabled" and an error message perhaps...but not a "panic".

Anyway...onwards.

I am now running: macOS 12.1 (21C52) on an M1

So, I have now started re-using the 

Satechi Slim USB-C Multiport Adapter with Ethernet

For the 1st few hours, when forcing a sleep, and then a wake.

I am now using it in real life, and it has behaved for a few hours now.

However, the older USB 2.0 HUB, which was working all the way through this saga, is now causing a Panic.

It is now unplugged from M1, and relegated to other duties where it works well....sigh...

Again, I suggest to Apple, that a peripheral causing a Kernel Panic is "bad".

Perhaps just disable the HUB!? And give a message.

Nick,

We are end users just like you, Apple is simply our host and does not read or participate in these user to user forums. If you want something suggested to Apple please use www.apple.com/feedback and let them know.

Marykendell2,

Please create your own thread in the MBP forums. Posting the same symptoms in anothers thread can be confusing. You may have the same symptoms however the cause can be completely different which would be confusing for everyone.

Also, when you create your own thread please include the Kernel Panic report the computer produces. KP's can be difficult to diagnose as they can be caused by hardware and software.

Correct term for OSX is "Wake After Sleep".

The HUB in question is SATECHI USBC Multiport

Model: ST-UCSMA3M

I am having this issue too. Not sure if it is the update, but I have never had this issue before.