May I virtualization a Down arrow key press on Macbook keyboard in macos?

Finally, I found a solution.

I create a python script using pynput LIB, running on python3.

from pynput import keyboard
from pynput.keyboard import Key, Controller

keyb = Controller()

is_alt_pressed = False
is_shift_pressed = False
is_down_pressed = False
def on_press(key):
    global is_alt_pressed
    global is_shift_pressed
    global is_down_pressed


    if key == Key.shift_l:
        is_shift_pressed = True;
    if key == Key.alt_l:
        is_alt_pressed = True;

    if(is_shift_pressed and is_alt_pressed and (key == Key.up)):
        keyb.press(Key.down)
        is_down_pressed = True

def on_release(key):

    global is_alt_pressed
    global is_shift_pressed
    global is_down_pressed

    if(is_down_pressed):
        is_down_pressed = False
        keyb.release(Key.down)

    if key == Key.shift_l:
        is_shift_pressed = False;
    if key == Key.alt_l:
        is_alt_pressed = False;



# Collect events until released

print("Keyboard macros running...")

with keyboard.Listener(
        on_press=on_press,
        on_release=on_release) as listener:
        listener.join()

And allow all permission to bash shell (Terminal)