SOCKS proxy sometimes ignores "Bypass proxy" list

I use a SOCKS proxy to get to network resources in a private subnet. I have my "Bypass proxy settings for these Hosts & Domains" set so that I do not use the proxy for most internet traffic:

*.local, 169.254/16, *.com, *.net, *.org, *.us

This works as desired most of the time, but sometimes the bypass list is ignored and Monterey attempts to route all of my network through the proxy, which basically causes me to lose internet access. If I disable the proxy and then immediately re-enable, it usually works correctly. This is without making changes to the bypass list... I'm just unchecking the SOCKS proxy box, click OK, then re-enable.

A friend reports the same problem occurs much more frequently on her Catalina system.

What might be causing this intermittent problem? How can I ensure that my SOCKS bypass will never be ignored?