Have you tried running without the external FireWire drive connected?
disk4 - 1.00 TB
External FireWire Up to 800 Mb/sec
FireWire was another of Apple's "Hype it, then Heave it" initiatives and may not be well-supported in newer macOS version. Easy enough to test.
Look at the install dates for some on the extras. Example:
Internet Plug-ins:
Silverlight: 5.1.50901.0 (? - installed 2017-03-25)
AdobePDFViewerNPAPI: 17.012.20098 (Adobe Systems, Inc. - installed 2021-05-11)
AdobePDFViewer: 21.001.20155 (Adobe Systems, Inc. - installed 2021-05-11)
MeetingJoinPlugin: (? - installed 2017-03-18)
iPhotoPhotocast: 7.0 (Apple - installed 2013-04-20)
SharePointBrowserPlugin: 14.7.7 (? - installed 2017-09-16)
and, in User Launch Agents:
[Not Loaded] GrowlLauncher (App Store - installed 2013-10-30)
Modern Login Item
/Applications/Growl.app/Contents/Library/LoginItems/GrowlLauncher.app
Some are far older than the computer and therefore surely not optimized for Monterey. I suspect they came over because of Migration Assistant. Exactly why I don't use MA. If you still need those, update them, Otherwise evict them.
If those steps don't help, contact Apple SOON for a warranty assessment. KPs can be hardware-related and the usual suspects like loose or incompatible RAM don't; apply to Apple Silicon devices. If you have a hardware fault in that model, only Apple can fixit.