I cannot open any applications

ladygebtrt wrote:

I cannot open any application in email. Might have something to do with the notice that my time machine cannot save as it is full.

?

Mail.app us for opening email...

Did you try rebooting—I would Quit all open apps, reboot and and try again..

Log out, sleep, wake, restart or shut down your Mac

https://support.apple.com/en-mide/guide/mac-help/mchlp2522/mac

Maybe you can explain with more detail what is the issue.

Does this pertain to user profile MacBook Pro 15″, macOS 10.12 Sierra released in 2016

Or maybe this computer has been upgraded to Monterey macOS 12 ?

Change the default Browser to Safari