The application can't be opened -50

Well this is some type of " EndPointSecurity " process associate with this process

If, the user is truly interested in solving this Mystery >>

Understand, we are all working Remotely from all around the world. 

Therefore, we do not have the On-Hands experience the User ( you ) has with this computer.

The next best thing for us to having a semi - actual On-Hand experience  with this computer is to follow the steps below

Download the Application Etrecheck directly from a well Respected ASC Contributor. And Safe to use.

The application is free or paid from added features. 

Run the application with Full Disc Access ( Security & Privacy - Full Disc Access ).

It will take a Snap Shot -  both the hardware and software.

 The Report will Not Reveal Any Personal Information. 

Post back the Full Report - copy and paste - using the Additional Text Icon ( 3rd Icon to last )

We can have a look at the report for possible issues and may have possible suggestions to resolve the issues.

All the Below will appear in the Etrecheck Report. This added information is just to Assist the user identify potential Bad Actor Software

Any Third Party Applications that will interfere with the normal operation of the OS,  is an invitation for disaster and comprising the Operating System

Any of the below should be removed as per Developers Instructions 

This will include CleanMyMac , This will include BitDefender , 

This will included Norton Antivirus , Sophos Av Software

Intego AntiVirus, McAfee, MacKeeper, Avast AntiVirus

Ad Guard, Webroot , ESET

The The Built in Security  is all that is required.

Initially see one processes worth attention

1 - EndPointSecurity appearing in two locations is screen shot

This maybe related to BitDefender if installed on this computer.

If this is accurate and true >> Any of the below should be removed as per Developers Instructions 

This will include BitDefender  and please take a moment to read some of the Posting Specific to this Application and arrive at your own conclusions

Any of the below should be removed as per Developers Instructions 

Start by Opening the Activity Monitor Application >> View >> View ALL Processes.

It will list all Processes and Applications that are Loaded and Running.

Give us a Screen Shot, as best as possible, without revealing any Personal Information

We may be able to identify what is running that is causing this popup issue

Thank you for the Etrecheck Report

Will spend some time to Dissect the report in fine detail and get back to you shortly.

Should my Learned Colleague your question, pick up the Report before me - suggest following that advise also.

Quick question before combing the report in Full Detail Mode

Configuration profiles found - This computer may have configuration profiles installed. These are sometimes used by malware.

Is this computer Associated with / or Owned by a Company, University, or some Organization which required Enrolling the Machine in a Mobile Digital Management Service ( MDM ) ?

Configuration Profiles: This appears to a Company or University or Organization Computer registered with a MDM Service

Therefore - predicated on that as being True and Accurate -  There is little we can do to assist. 

That is because this computer is Controled by the MDM Profiles which are Controlled by the Entity that Enrolled This Computer 

You are Best to contact the IT Department for all and any issues this computer is experiencing 

Which application is not opening?

Have you installed the version compatible with MacOS 12.4?

Have you looked on the developer web site for possible answers?

See if this helps: Boot into safe mode to prevent apps from launching automatically at boot.