One of the SSDs either doesn’t offer TRIM, or isn’t enabled for TRIM. Which can mean heavy I/O to that will be limited by the speed of the erasure.
Multiple anti-malware apps, as mentioned above. Pick one, at most.
Java. I’ll assume some app here is using that. Java 8 is an old version, and u333 is the current (last?) of that line. You have u291. Java updates tend to be for security or for stability, and Java itself tends toward resource-intensive.
I don’t know what performance implications might exist for that Intel kext. Intel can tailor their processors for speed, or for efficiency. Intel Power Gadgets, etc.
Add-on VPN apps can slow down traffic, and some can monitor and log. Absent website testing or related geoshifting, they tend to provide less than what might be wanted, and can provide surprises.
I’ll assume there’s some Windows app that requires CodeWeavers.
Your I/O performance looks pretty good, as does your CPU.
Spotlight and mail are active. Busiest is some of your anti-malware. Mail got tangled with something, Spotlight too, and Edge and Firefox hung. As a test, I’d remove the anti-malware. Malware on Mac tends to be adware or similar stuff deliberately installed by the user, so is that really malware?
There has been some targeted Mac malware recently, and I’ll assume you’re not involved in defense-related work, where that was purportedly targeted. If you are, check with your organization’s security folks.
Usenet for postings is fine, but Usenet for other uses including cracked apps can be Really Hazardous.
There is no need for secure file deletion on an encrypted SSD. SSDs work very differently from HDDs.
TL;DR: remove the add-on anti-malware and see if things stabilize.
