Mail app really CPU-hungry
Somebody else asked this about the new Monterey OS, but I'm still running Catalina (10.15.7). I've noticed my computer being really slow (e.g. I type a sentence and then wait twenty seconds for it to be echoed), across a wide range of apps, for weeks or months. I fired up Activity Monitor, and it said Mail was using 115% of my CPU.
So I quit the Mail app, and things improved immediately:
Among other things, the computer is having no trouble keeping up as I type this :-)
iMac 27″, macOS 10.15