Thanks P. Philips for your time and detailed responses.
I'm in the process of preparing for a full backup, clean install and recovery manually. This OS has been continually migrated, transferred and updated since 10.6 Snow Leopard.
I rely so heavily on minimal downtime with the production environment I operate, it's just easier that way.
Heavy CPU usage - yep - it's Mail.Web.Content doing that! that's what i'm trying to solve. I had mail running when I did the EtreCheck scan, as the machine is fine unless i run Apple Mail.
Orphan, unsigned apps, system mods - all will be reviewed and possibly removed, however the same sets of unsigned apps and mods are installed on another identical model iMac in our office (also running Ventura), and no issues are present with it's Mail.Web.Content.
Malwarebytes has been one for the least intrusive and lowest resource hungry utils I've used since clamXAv in the early macOS X days. I'm doubtful, but will turn the App Block and Malware Protection off to see if that assists.
Macs Fan Control has been helpful to set a higher static fan speed, as macOS was not lifting the fan speed to counteract the higher internal temperatures, especially since Mail.Web.Content started kicking off.
The default macOS fanspeed is 1200 rpm. I've lifted that minimum to 1500rpm, with the fan speed rising proportionally as the CPU average temp rises from 55C, with the 95C being the max allowable temp. We live in a high ambient temperature country, with daytime summer temperatures which can exceed 40C (100F) for a week at a time, and overnight temps not dropping much below 30-35C, thus the indoor temperature can be higher than the expected ambient of 21C (our air conditioners struggle).
Unless you or others have differing suggestions, and the above A1-A6 don't prove effective, it's a wipe and clean install as the only option, I believe.
Thanks for the help.