I found a solution that might work for you. If your headphones are connected to two devices at the same time, e.g., iMac and iPhone, disconnecting and completely removing them from one device will significantly improve the audio quality. I was able to reduce the stuttering of my Bose QuietComfort 45 from once every 3 minutes to once every hour by using them exclusively with my iMac. I removed them from my iPhone's list of Bluetooth devices and also deleted the Bose app to prevent it from reconnecting.
Right now I have five Bluetooth devices connected to my iMac, including the Bose headphones, so, at least in my case, having multiple devices connected to the machine wasn't the culprit.
I also don't have interference issues because I only started experiencing severe stuttering after upgrading to macOS Ventura (13.3.1a) from Big Sur and the arrangement of the Wifi router, USB hubs, and all Bluetooth devices in my study remain the same throughout this stuttering ordeal.
For your information, I tried the following recommendations to no avail:
- Delete the Bluetooth preference, i.e., com.apple.Bluetooth.plist.
- Factory reset the bluetooth settings using sudo pkill bluetoothd.
- Remove and re-add the Bose headphones.
- Disable AirPlay Receiver
I also experience stuttering with AirPods Pro, but I'm reluctant to use AirPods exclusively on one device. If you don't have any other Bluetooth ear/headphones and are tired of your AirPods stuttering, you might want to try the above suggestion too.
Let me know if this helps!