Confirm you are booting from this external SSD?
disk1 - TS1TSJM500 1.02 TB (Solid State - TRIM: No)
External Thunderbolt 6 Gigabit Serial ATA
It appears so because your drive read/write scores are far above what the internal factory mech drive can do (always under ~80MB/sec). However, those scores:
Performance:
System Load: 5.44 (1 min ago) 4.75 (5 min ago) 3.33 (15 min ago)
Nominal I/O usage: 20.35 MB/s
File system: 24.21 seconds
Write speed: 194 MB/s
Read speed: 308 MB/s
are below expected for a drive with those specs. They should both be about 400MB/sec for a compatible external SATA 6G SSD in a USB3 enclosure, and faster for Thunderbolt. I don't know whose SSD Transcend used but, when it comes to Macs, Crucial and OWC have been most compatible.
You can try enabling TRIMforce on the SSD. That might bring up the low Write speed. It helps when the Write speed dropped on one of my aftermarket SSD's after abotu three years of use. NOTE: You will need to use Safe Mode starts several times before the change fully takes effect. Let the computer sit idling in Safe Mode for at least an hour each time to do all teh housekeeping. Repeat until the score increase.
PLEASE let your Mac be a Mac. You have installed gobs of useless third-party stuff:
...what I use to monitor and clean memory hogs is Extreme Clean Memory
A simple restart always cleans the RAM. That app is redundant.
- You had CleanMyMac installed at one time. It will slow drive performance...I've seen that in dozens of Etrecheck reports. The macOS is self-cleaning; you just threw a wrench in that elegant design by adding a conflicting "cleaner" app. They are all useless.
- No anti-virus is need or recommended. Ignore "fear" marketing/.
- You have both Seagate and Western Digital software install that probably can with an external drive. Those need to go.
One of these is probably causing WebKit (an underlying technology in Safari), to be RAM hungry:
Safari extensions:
Antivirus One - /Applications/Antivirus One.app
Grammarly for Safari - /Applications/Grammarly for Safari.app
Evernote Web Clipper - /Applications/Evernote Web Clipper.app
I go for voting #1 off the island to start.