Perhaps. Please review Optimize storage space on your Mac - Apple Support. Its Reduce Clutter option will identify seldom used apps and files for you to review. Choose "Show in Finder" to navigate directly to them so that you can decide whether to delete them, or move them elsewhere.
Although you did not ask, bear in mind that Time Machine will only back up an item once, unless of course a change is made to that item. You can also exclude specific items from being backed up: Exclude files from a Time Machine backup on Mac - Apple Support. If you choose to move all those items to a separate folder and exclude it, that might also be a solution to consider. Although that document's title implies you can only exclude files, you can exclude entire folders or even connected devices such as hard disk drives or flash drives. A more accurate title would be "Exclude items from a Time Machine backup".