I cannot open files(especially PDF files) after update ventura 13.2.1 to 13.3

Try booting into Safe Mode which clears out caches and performs some other maintenance that can resolve bizarre problems.

On Intel Macs:

1. Shutdown completely
2. Hold Shift key while powering on and keep holding till you get to a login screen
3. Let go and login. You will see a second login screen and it usually says Safe Mode in red on the menu bar at the top.
4. Login again and wait, it will be slower to boot to the desktop. The Dock should have lost its transparency.
5. Give it about 3-5 minutes then shutdown and boot normally

On Apple Silicon Macs:

1. Shutdown completely
2. Press and hold the power button and keep holding it
3. Click on Options and you will see your boot disks Macintosh HD, etc.
4. Hold shift key on the boot drive and it will change to Safe Mode
5. Select and boot macOS
6. There will be two login screens and it should say Safe Mode at the top menu bar
7. The dock transparency will be gone
8. Give it about 3-5 minutes then shutdown and boot normally.

Let us know if the problem persists or not.