The message is telling you that to get Wacom to work as they feel it should, you have to make changes, specifically those in the message itself.
Remember, you just upgraded to a more secure version of macOS and some security requirements may have changed. This is not uncommon.
In nothing works, Wacom is going to have to advise you as this is not an Apple product and they are responsible for updating their products to work with macOS. Or not if they decide not to .
