How do I set up second Apple ID in a second region without losing subscriptions, etc.?

Hi,

I'll attempt to answer your questions instead of simply giving you the instinctive response and support article link to you having mentioned the words "Apple ID" and "country". I hope you make it this far and read all responses to your question.

Two-region issue - I understand it is possible to set up a second Apple ID for my second region, and switch between them. However, can I do this without losing subscriptions, iTunes purchases, etc., and continue using my iCloud subscription in the original region?

First, I note that you are NOT talking about changing country settings on a single account, so a priori this document does not necessarily apply as written: Change your Apple ID country or region - Apple Support

Nevertheless some of the requirements will have bearing upon what you wish to do.

I very much doubt you can achieve what you want, particularly since you are using mobile devices which can only be signed into one account at a time, plus it involves subscriptions which will require you be signed in with that account in order for them to work. If you were just referring to items such as music tracks which you had purchased, those will remain on a device until removed regardless of the ID that that is signed in. Apple does not intend that a user have more than one account unless you need an entirely different persona that is completely separated from the first, plus Apple has things set up so an account is affiliated to a single region at a time.

There could be a bunch of other issues such as payment methods, though it sounds like you and your wife may be in different countries so that may be a way to arrange for that?

Also, is it possible to have family sharing across regions? (I figured I'd ask anyway :-)...) My wife and I have iPhones, and we share an iPad.

No.

Legal - Apple Media Services - Apple

"All Family members must share the same Home Country."

Share purchases with others in your Family Sharing group

Share purchases with others in your Family Sharing group on Mac - Apple Support

"To share purchases, family members must be in the same iTunes Store country or region."

If you change Country or Region, you must comply with all regulations described here ->  Change your Apple ID country or region

Change your Apple ID country or region - Apple Support (KW)

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What to do before you change your country or region

• Spend any balance remaining on your Apple Account balance. If you're not sure whether you have a balance, check your Apple Account balance.
• Cancel your subscriptions and wait until the end of the subscription period. 
• Wait for any memberships, pre-orders, movie rentals, or Season Passes to complete, and wait for any pending store credit refunds to process. You can cancel a pre-order.
• Make sure that you have a payment method for your new country or region. See what payment methods you can use.
• Redownload your apps, music, movies, TV shows, and books on any devices that you might use to play or read them in the future. Some types of content might not be available in your new country or region. Learn what types of content and services are available in your new country or region.

1.

You need to ZERO your Apple Account balance, it is depending on the amount:

1.

If your balance is less than the cost of a single item, contact Apple Support directly, they will help you clear your Apple Account balance: Get Support

2.

See -> Check your Apple Account balance

Check your Apple ID balance – Apple Support (UK)

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If you have Apple Account balance you can't use.

You can't redeem or return Apple Gift Cards, App Store & iTunes Gift Cards or unused Apple Account balance for cash, except as required by law. If your jurisdiction allows the refund of redeemed gift balances, you can contact Apple Support to request a refund. 

When you contact Apple, include the following information:

•           Your Apple ID.

•           The refund amount.

•           Your current delivery address. 

2.

You need to Cancel your subscriptions and wait until the end of the subscription period. 

3.

Make sure that you have a payment method for your new country or region. See what payment methods you can use.

You need to have a debit / credit card issued by a bank in your new country.

You need to have a billing address in your new country.