Although it may appear to be a 'pointer not recognized adequately' problem, cursor-position updates are performed at very low priority in the background. Seeing hesitating and jerkiness is an indication there is too much CPU-hogging going on, and if you are seeing that in Safe Mode as well, then your report from Safe Mode will be adequate to draw some conclusions.
The first issue is a VPN you installed yourself. These are NOT benign, and are NOT appropriate unless you are in an iron curtain country and need a VPN to get to the outside world. If you are in a witness protection program, you should use Tor Browser, not a VPN. Otherwise, VPNs you install yourself punish performance, Actually REDUCE your security and cause misery in many different ways. Remove that VPN at your earliest convenience and NEVER re-install it.
Non-native File syncers (you have backBlaze installed) are as bad as third-party Virus scanners, in that the default way they run is to scan your files, and fast as they can, non stop, looking for changed files. Mac-native File syncers use the Mac File System Event store to learn instantly what folders have changed. If you MUST use BackBlaze, you should run it only on demand, and quit it when synced. If you are using BackBlaze as a backup mechanism, that is a much larger problem, and we need to have a MUCH longer talk.
You pay a performance penalty for using tools like Trello and Docker. if you can quit those when not in use, performance would be far better.
Chrome. Is the biggest resource-hog that is not blatant malware. You should try to transition to a different Browser such as FireFox or Safari to gain substantial performance improvement. in the meantime, Quit Chrome when you really want to do something on your Mac -- yes, it really is that bad.
I do not know about Adobe content synchronizer, but my suspicion is that it is another one of those reads-your-files-non-stop ported to Mac syncers, and should be turned OFF almost all of the time, and only activated for a brief few minutes to sync, then quit.
Again, if you consider this BACKUP, we need to talk about that.
Evernote may be a great note-taker, but if it synced your files as well, your should limit when it scans your files for sync.
