This was originally a Windows-only device. There is only limited support for it on a Mac. This 'limited' support is basically low-level printing support only. There does not appear to be any support for the scanner section for anything other than Windows.
As this was not one of Epson's more popular devices, 3rd-party support is also limited. It is unlikely that you will get 3rd-party scanner support if VueScan doesn't work.
This device is discontinued. This means that support from Epson will be even more limited in the future than it is now. Translation: if it doesn't work now, odds are good that it will never, ever, work.
I'd get a new MFD. Preferably one which ships with Mac support in the box. Brother, Canon, HP, and, yes, Epson, all make machines which will work. (I'd stay far away from Lexmark, but that's me.)