Beach balling on 2019 27" iMac - 64GB memory and 3 Tb HDD

First uninstall the 3rd party AntiVirus programs.

a) MacOS is pretty secure on its own. I'm only aware of a single MacOS virus seen in the wild in the past five years (DazzleSpy). Everything else targeting MacOS has been trojans users are tricked into installing themselves.

b) AntiVirus with active background scanning works by installing hooks into the system to watch for suspicious activity. Those hooks will slow your system down. Added security comes at the price of performance.

Second rerun Etrecheck and post the full report using the "additional text" posting option.

First, there is no reason to ever install or run any 3rd party "cleaning", "optimizing", "speed-up", anti-virus, VPN or security apps on your Mac.  This documents describe what you need to know and do in order to protect your Mac: Effective defenses against malware and other threats - Apple Community and Recognize and avoid phishing messages, phony support calls, and other scams - Apple Support.  

There are no known viruses, i.e. self propagating, for Macs.  There are, however, adware and malware which require the user to install although unwittingly most of the time thru sneaky links, etc.   

Anti Virus developers try to group all types as viruses into their ad campaigns of fear.  They do a poor job of the detecting and isolating the adware and malware.  Since there are no viruses these apps use up a lot of system resources searching for what is non-existent and adversely affect system and app performance.

There is one app, Malwarebytes, which was developed by a long time contributor to these forums and a highly respected member of the computer security community, that is designed solely to seek out adware and known malware and remove it.  The free version is more than adequate for most users.  

Unless you're using a true VPN tunnel, such as between you and your employer's, school's or bank's servers, they provide false security from a privacy standpoint. 

As you've already been told uninstall the A/V apps according to the developers instructions. You can check to see if you've removed all of the supporting files by downloading and running the shareware app Find Any File to search for any files with the application's or the developer's name in the file name.  For XXXX software you'd do the following search(es): 

1 - Name contains XXXX

(get the names from the Etrecheck report)

Any files that are found can be dragged from the search results window to the Desktop or Trash bin in the Dock for deletion.

FAF can search areas that Spotlight can't like invisible folders, system folders and packages.  

If you get warnings that the file can't be deleted because it is in use or used by another app boot into Safe Mode according to How to use safe mode on your Mac and delete from there.

Note:  if you have a wireless keyboard with rechargeable batteries connect it with its charging cable before booting into Safe Mode.  This makes it act as a wired keyboard as will assure a successful boot into Safe Mode.

Please post the full EtreCheckPro report, as per > How to use the Add Text Feature When Post… - Apple Community

From the small amount of info that has been offered so far. It looks like you have installed multiple unnecessary antivirus apps and some apps that have made a large number of system modifications.