Slow app startup after reboot

Delete these files & restart...

/Library/LaunchAgents/com.amazon.sendtokindle.launcher.plist

/Library/LaunchDaemons/PACESupport.plist

/Library/LaunchDaemons/com.smithmicro.schedulerdaemon.plist

/Library/LaunchAgents/com.epson.eventmanager.agent.plist /Library/LaunchDaemons/com.aladdin.hasplmd.plist

/Library/LaunchDaemons/com.aladdin.aksusbd.plist

/Library/LaunchAgents/com.epson.esua.launcher.plist

~/Library/LaunchAgents/com.adobe.ARM.***.plist

~/Library/LaunchAgents/com.apple.SafariBookmarksSyncer.plist

~/Library/LaunchAgents/com.amazon.music.plist

~/Library/LaunchAgents/com.adobe.ARM.***.plist

~/Library/LaunchAgents/ws.agile.1PasswordAgent.plist

~/Library/LaunchAgents/com.smithmicro.cleaning.schedulermailer.plist

~/Library/LaunchAgents/com.adobe.ARM.***.plist

~ tilde indicates your home folder

Apple hid the Users' Library folders...

Method 1:

1 From the Finder, select the Go menu at top of the screen, and choose Go to Folder.

2 In the window that opens, enter ~/Library, and click Go.

What are the read and write speeds in the Etrecheck report that you ran?

Rather than ask question after question just post the Etrecheck report as follows: Copy the report

and use the Additional Text button to paste the report in your reply.

Then we can examine the report and see if we can determine the cause of the problem.

If we find the the current boot drive is inadequate or failing a better solution would be to get an external SSD, clone your boot drive to it with Carbon Copy Cloner and boot and run from it. We'll know more after you post your report.

Did you maybe enable iCloud Drive?

Delete these files & restart...

/Library/LaunchAgents/com.xrite.device.softwareupdate.plist

/Library/LaunchDaemons/com.aladdin.aksusbd.plist

/Library/LaunchDaemons/com.aladdin.hasplmd.plist

Have you installed and run any "cleaning", "optimizing", "speed-up", anti-virus or VPN apps on your Mac?

Give this a try: boot into Safe Mode according to How to use safe mode on your Mac and test to see if the problem persists. Reboot normally and test again.

NOTE 1: Safe Mode boot can take up to 3 - 5 minutes as it's doing the following; 

• Verifies your startup disk and attempts to repair directory issues, if needed

• Loads only required kernel extensions (prevents 3rd party kernel/extensions from loading)

• Prevents Startup Items and Login Items from opening automatically

• Disables user-installed fonts 

• Deletes font caches, kernel cache, and other system cache files

NOTE 2: if you have a wireless keyboard with rechargeable batteries connect it with its charging cable before booting into Safe Mode. This makes it act as a wired keyboard as will insure a successful boot into Safe Mode.

How about another etrecheck report to see if somethig elsegotuncovered?

You can use Drive DX to possibly get a better view of Drive health…

https://binaryfruit.com/drivedx

Replacing the drive yourself is not officially supported, but if you have the skills to do it, it would be worthwhile. Until last year I had a 2013 iMac with an upgraded drive. It Is only because the power supply failed that I had to replace that unit

Your Mac is not too old for Ventura, but it can be a bit old on its internal SSD or FusionDrive therefore booting apps if they are completely closed can take a bit longer.

My old windows pc (2 years) is taking 15 minutes to open some apps, so 50 seconds to 2 minutes is really acceptable for a machine from 2017

iCloud Drive may be the reason Desktop & Documents folders disappear.