Try and boot the Mac in the safe mode to see if you can find the speaker in the safe mode. If you can, there is a problem with external software when not in the safe mode
Steps for booting your Mac in the safe mode differ wether you're using a Mac with apple silicon or an intel mac
Start up your Mac with Apple silicon in safe mode
- On your Mac, choose Apple menu
> Shut Down. - Wait for your Mac to shut down completely. A Mac is completely shut down when the screen is black and any lights (including in the Touch Bar) are off.
- Press and hold the power button on your Mac until “Loading startup options” appears.
- Select a volume.
- Press and hold the Shift key, then click Continue in Safe Mode.
- The computer restarts automatically. When the login window appears, you should see “Safe Boot” in the menu bar.
Start up your Intel-based Mac in safe mode
- Turn on or restart your Mac, then immediately press and hold the Shift key until you see the login window.
- Log in to your Mac.
- You might be asked to log in again.
- On either the first or second login window, you should see “Safe Boot” in the menu bar.