First, start your Mac in "Safe Mode": How to use safe mode on your Mac - Apple Support. Starting in Safe Mode takes longer than usual so let it finish.
While in that mode, drag all the files in those three folders to the Trash except those with the following in their names:
Adobe
Canon
Epicgames
ExpressVPN (but read • later)
Google
Microsoft
Razer
Skype
Valvesoftware
Xquartz
Zoom
Everything other than those files with the above in their names should be deleted.
Then, restart your Mac normally.
- Regarding ExpressVPN be sure to review Don't use VPN services. This isn't the cause of the problem, but it doesn't help.
Launch Safari but press and hold a Shift key while launching it as you usually do. That's optional but will ensure it will not start with that same problematic web page, which might make you believe you didn't fix anything. Release the Shift key when the Safari window opens. If you still experience the problem please write back for some additional steps that might be necessary.