I started with a 36 MB 100% jpg image from a Lightroom RAW edit, cropped it in Photos, and then blew it up 2000% from there. I compared a TIFF export (6MB), a jpg Max export (1.5MB), and the Lightroom jpg. The export sizes represent lots of cropping, not loss of quality. Pixels were pretty big! But I didn't see any real difference. Here is some blue sky next to an Eagle's head:

I thought the blue sky would be most susceptible to compression. I'm not sure how this survives the web upload, but, really, they look the same. The Eagle's eyelash looks the same, as well.
The TIFF export is 4 times as big, but looks the same as the 100% jpg. I'm not sure what the point of using TIFF would be…