I don't see any of the usual suspects. However, you may have a failing HDD in your Fusion drive:
Write speed: 229 MB/s
Read speed: 2250 MB/s
It's been 22 days since you've rebooted your Mac. You should reboot at east once a. week or more to clear out the temporary system and application swap and cache files. To start with boot into Safe Mode according to How to use safe mode on your Mac and reboot normally.
NOTE 1: Safe Mode boot can take up to 3 - 5 minutes as it's doing the following;
• Verifies your startup disk and attempts to repair directory issues, if needed
• Loads only required kernel extensions (prevents 3rd party kernel/extensions from loading)
• Prevents Startup Items and Login Items from opening automatically
• Disables user-installed fonts
• Deletes font caches, kernel cache, and other system cache files
NOTE 2: if you have a wireless keyboard with rechargeable batteries connect it with its charging cable before booting into Safe Mode. This makes it act as a wired keyboard as will insure a successful boot into Safe Mode.
Also the Adobe Illustrator is using 114% of the CPU. Make sure you have the latest update for it.
You can download and run the free version of DriveDX to see how the heath of your Fusion Drive is.
If it tells you it's fading an easy workaround for it is to get a Thunderbolt external SSD, clone your boot drive to it with Carbon Copy Cloner and boot and run from the external SSD. That should get you much faster system performance particularly in the read speed.
If you go the route of the external SSD I recommend you contact the OWC (MacSales.com) Customer Support to see which of their several external SSDs best suit your Mac model, work requirements and budget. OWC is considered by many here to be the premier 3rd party hardware supper for Macs.