compatibility of Office Home and Business 2021 to newer OS

Microsoft says it's compatible with Sequoia -> https://support.microsoft.com/en-us/office/upgrade-macos-to-continue-receiving-microsoft-365-and-office-for-mac-updates-16b8414f-08ec-4b24-8c91-10a918f649f8

Quote:

"Office for Mac 2021-2024

As of September 2024, the three most recent major versions are macOS Sequoia, macOS Sonoma, and macOS Ventura.

Starting with the September 2024 update (16.89) macOS Ventura or later is required to receive updates to Word, Excel, PowerPoint, Outlook, and OneNote. If you continue with an older version of macOS, your Office apps will still work, but you'll no longer receive any updates including security updates."

The answer is yes. My Office 2021 for Mac Home and Business never misbehaved going from Sonoma to Sequoia v15.3.1.