To be clear, the fact that you can scan directly into an application usually means that the application uses the driver that comes from the manufacturer to scan, and the result appears in the application. So whether you scan into Preview, Image Capture, or use the manufacturer's scanning application, the scan is the same. The difference in how you can save the scan is in the application, not in the driver. So there is no reason not to at least try the manufacturer's scanning application.
There are a few applications that provide alternate drivers, including VueScan, although it does not provide the drivers for all scanners. With those applications, you may get different scanning results than with the manufacturer's driver.