Yes, but it won't be as easy as synching with an i-device. I have a Sansa player as well as a RCA MP3 player. With both devices you can simply copy mp3 files to them. As long as the mp3s are tagged correctly you can arrange by artist, album etc amnd play that way. If you want playlists things get a bit tricky. Neither player has software that supports OSX so playlists on the Sansa either have to be created by hand or using a third party script.
If your computer can run Windows you can use the software that way, otherwise there is a moderate degree of inconvenience, especially if playlists are important.
