I purchased a Planet Waves (6 pin) Firewire cable. That allowed the unit to power up from the Firewire connection, prior to that, it wouldn't power up without using the "wall wart" power supply so. the stock firewire cable was defective
I updated to the latest 2.2 version (today) of Saffire, after contacting Focusrite's support. I have uninstalled the application, did the permissions reset in the disk repair (as suggested by foucusrite), re-set my firewire bus (shut down, disconnect power, wait, reconnect, boot up), in short, I have covered a lot of bases in the last few days. Every time i try to start the Saffire Mix control a message of "No Hardware Connected" comes up. Saffire does not show in my Logic Pro Studio * Preferences>Audio> Devices list. Saffire does not show in About this Mac> More info. Hardware>firewire... all I get under the Firewire tree is Unknown Device, etc. The tech from Focusrite said there are issues with combination firewire 400/800 cards, but mine also has a 400/USB on the front that I have the unit plugged into (yes, I have tried both front and rear) and, there are no other firewire units of any sort plugged into the Mac.
I am thinking the unit is defective but I want to exhaust all of the possible fixes before I return it... Any ideas? Any help is sorely needed, and greatly appreciated.