I have a mid-2013 model Mac Mini. It’s been working fine with a 4-port USB 3.0 Anker hub which came with a power supply. Recently, however, my Mac Mini would never wake up if I put it to sleep. It was absolutely impossible to wake up. I did the usual things, like resetting PRAM and the SMC controller. Nothing worked. The only thing I could do, if the computer went to sleep and then into a coma, was to pull out the power cord from the Mac Mini and restart.
The only thing that had changed was that I had put in a new USB hub. I had purchased a new USB 3.0 HooToo hub that had no power supply. I had put an old power supply from a cell phone on it (it was rated to output 0.5 amps). Pulling out the USB hub while the Mac mini was in a coma did not work, so I did not think that the USB hub was the problem.
I did more reading on forums, and a few forums gave me the solution to my problem. The problem is that a USB hub connected to a Mac requires a lot of power if there are a lot of devices connected to it. If that USB hub does not have enough power, then for some reason the Mac that the USB hub is connected to will go into a coma. It simply will not wake up from Sleep.
My older Anker 4-port hub came with a power supply that is rated to output 2.5 amps. I connected an old Apple ipad charger to my new HooToo USB hub. This power supply supplies 3.0 amps, and the Mac Mini is now waking up from sleep just fine – and super quickly. I think that the problem is solved.
I can see that there is a Hootoo hub on Amazon now that sells with a 4-amp charger. The older Hootoo hub that I bought, and which did not come with a charger, is discontinued.
Summary: If you are having problems waking up your Mac or PC from its sleep state, then see if the problem is being caused by your USB hub. If taking the USB hub off your laptop solves the problem, then look into providing more power to your USB hub.