I too have had this problem. Doesn't matter what browser, full screen or not, and it happens randomly. I may just open a page in another tab and that other tab starts loading a flash ad.
Happens either waking from sleep, or a fresh restart (I just turned my computer on this morning and it happend) Java installed. Perian and Flip4Mac installed. Screen Sharing (and Back to my Mac) off. I typically have the Mail app open as a full screen app.
This is on a Mid 2010 Macbook Pro w/ Core i5, 8GB RAM, SSD and HDD (for storage), GeForce 330M.
Interesting things to note:
First the browser chokes. Then, as I have iStat Menu installed, I have a live view of my CPU cores. I can see that one core gets hit hard, it goes 100% immediately. Getting more detail though, shows me nothing that's using any more than 10 percent of my CPU, which is bizarre. I should be seeing something that says "evilWebProcess - 100%"
I try to force quit, which then causes the entire system to lock up. I can move my mouse around, but nothing is responsive. Only solution is a hard restart.