Tips to Speed Up Lion
1. Remove Adobe AIR. Use the latest non-beta Adobe Air Install .dmg and the command line process. It's a PITA, but you can Google how.
2. Remove SIMBL and associated apps. Also Google that.
3. Uncheck "reopen windows when logging back in" at shutdown. My login items would pause after login when I left iTunes, Mail and iCal open at shutdown with this feature. When I uncheck it - even if I open Mail, iTunes and iCal as Login Items - everything is lightning fast.
Lion has been great for me, but I had two issues:
1. Apple Mail would beachball for a few seconds every few minutes.
2. On restart, after login, loading of many login items would hang for 30 seconds after the core Apple stuff would load.
The above steps have made Lion smooth and fast for me.
-Adam
Mac Pro (2010) 2 x 2.93 GHz 6-Core, 48 GB 1333, Mac OS X (10.6.4), ATI 5870, OWC SSD Boot