how do i set the kodak esp 5250 printer up for duplex printing?

What Mac and what version OS do you have?

This is from their website for your printer. How far can you get on this list?

Printing two-side documents from a computer with MAC OS

To print two-sided documents from a computer with MAC OS:

1. Load paper into the paper tray.
2. Open the document you want to print, then select File > Print.
3. In the Print dialog box, make sure that Eastman Kodak Company ESP 5200 Series AiO (or for a wireless connection, KodakESP5200+XXXX, where XXXX is a number) is selected.
4. In the Copies & Pages drop-down list, select Paper Handling.
5. In the Pages to Print drop-down list, select Odd Only.
6. In the Page Order drop-down list, select Reverse.
7. Click Print.
8. When the odd pages have finished printing, remove them from the output tray.
9. Rotate the printed pages 180 degrees, and place them into the paper tray (printed side up).
10. Select File > Print.
11. In the Copies & Pages drop-down list, select Paper Handling.
12. In the Pages to Print drop-down list, select Even Only.
13. In the Page Order drop-down list, select Normal.
14. Click Print.

You're welcome. Since it's new I'm sure AppleCare will try to help, but it isn't their printer. If you can uninstall and reinstall that's probably what they'll suggest anyway.

Thanks Dave B.

When I first got the printer (right after it was introduced), The option for two sided printing was available in the print options, but after it disappeared with updates either to OS X or the Kodak software, I just gave up on it. I found your post and it made my night.

Thanks again!

You're welcome, so glad it was helpful!