Hi, Dudley. It looks like Iomega has abandoned the old and now very obsolete Zip 100 technology in favor of newer, larger, faster, more reliable, longer-lived, and higher-capacity removable media, notably the 35GB-per-cartridge Rev technology. I doubt that either Iomega or Apple will bother to write a driver for Zip 100 drives that is compatible with any recent version of OS X, never mind any future version.
When a 100MB Zip disk costs around $5 (when you can still find them), a 700MB CD-R costs 15 cents, a 4.7GB DVD-R costs $2, and huge, fast hard drives go for $.30-.$35/GB, there's just no reason to keep using Zip100 drives or disks. Put Zip's very high costs together with the very limited lifespan of a Zip disk, and you get a technology that is dead, dead, dead.
Find an old Mac that can still read your Zip disks, copy everything off all of them onto a FireWire hard drive, and say goodbye to Zips.