I actually have "seen" 8GB FBDIMMs. Thought all FBDIMMs were ECC, could be wrong.
They were designed for servers in a temperature controlled environment where they would be kept below max operating temperature.
You can buy and add RAM heatsinks and one Mac vendor sells a fan kit to put in the Riser cage.
But this is the first time I have heard of anyone putting more than 32GB in 3,1.
As for 667, the 4% hit that Barefeats found is miniscule and outweighed also by having all 8 DIMM slots populated which gets 17% boost compared to less than 8 DIMMs (number, not 8GB size).
So as long as you have say Hardware Monitor and set it to alert if any memory sensor gets a reading above 72*C - be nice to tell the fans via SmcFanControl to crank rpm up to 1200 rpm perhaps? Heat would be only issue as long as they show up and work and don't cause any trouble.
I would run some tests, and of course you can force the machine to boot 64-bit kernel in order to make best use.
Apple Pro RAID card didn't seem to like more than 48GB but then it doesn't like 3TB disk drives either. there may be other things too.