This is just an update. I replaced my drives, and as I installed new software, I would periodically check for broken soft links.
Summary
===
* Wrote a busted link detector; runs much faster than the script versions. It reports all links that don't link to a file or directory.
* So far, no corrupted links have been detected: however there are broken links. I haven't looked into the broken links to determine if they are expected behavior or not.
* All Applications were installed via App Store
* HomeBrew and packages were installed without sudo
* No browser plugins were installed (flash, silverlight, etc.)
* No drivers were installed
* sudo was only used to detect broken links
Steps
===
Rebuilt my machine:
* MacPro Mid 2012; 2 x 2.4 GHz 6-Core Intel Xeon; 32 GB 1333 MHz DDR3 ECC; ATI Radeon HD 5770 1024 MB
* Replaced all 4 drives with WD Red 3TB
* Configured raid 0/1 striped pairs, and then mirror
* Install 10.8.3
Broken links:
Missing link target: /Library/Frameworks/AEProfiling.framework->../../Applications/Motion.app/Contents/Frameworks/AEProfiling.framework
Missing link target: /usr/share/java/Tools/Java VisualVM.app/Contents/Resources/VisualVM.icns->/System/Library/Java/Support/VisualVM.bundle/Contents/Resources/VisualVM.icns
* Install xcode via App Store
Missing link target: /Applications/Xcode.app/Contents/Developer/Platforms/MacOSX.platform/Developer/SDKs/MacOSX10.7.sdk/System/Library/Frameworks/OpenGL.framework/PlugIns->Versions/Current/PlugIns
Missing link target: /Applications/Xcode.app/Contents/Developer/Platforms/MacOSX.platform/Developer/SDKs/MacOSX10.7.sdk/System/Library/Frameworks/System.framework/Versions/B/Resources/BridgeSupport/System.bridgesupport->../../../../../../BridgeSupport/libSystem.bridgesupport
Missing link target: /Applications/Xcode.app/Contents/Developer/Platforms/MacOSX.platform/Developer/SDKs/MacOSX10.7.sdk/usr/lib/python2.5->../../System/Library/Frameworks/Python.framework/Versions/2.5/lib/python2.5
Missing link target: /Applications/Xcode.app/Contents/Developer/Platforms/MacOSX.platform/Developer/SDKs/MacOSX10.7.sdk/usr/libexec/SmartCardServices/drivers/ifd-ccid.bundle/Contents/MacOS/libccid.dylib->libccid.dylib.1.3.11
Missing link target: /Applications/Xcode.app/Contents/Developer/Platforms/MacOSX.platform/Developer/SDKs/MacOSX10.8.sdk/System/Library/Frameworks/OpenGL.framework/Resources->Versions/Current/Resources
Missing link target: /Applications/Xcode.app/Contents/Developer/Platforms/MacOSX.platform/Developer/SDKs/MacOSX10.8.sdk/System/Library/Frameworks/System.framework/Versions/B/Resources/BridgeSupport/System.bridgesupport->../../../../../../BridgeSupport/libSystem.bridgesupport
Missing link target: /Applications/Xcode.app/Contents/Developer/Platforms/MacOSX.platform/Developer/SDKs/MacOSX10.8.sdk/usr/lib/python2.5->../../System/Library/Frameworks/Python.framework/Versions/2.5/lib/python2.5
Missing link target: /Applications/Xcode.app/Contents/Developer/Platforms/MacOSX.platform/Developer/SDKs/MacOSX10.8.sdk/usr/libexec/SmartCardServices/drivers/ifd-ccid.bundle/Contents/MacOS/libccid.dylib->libccid.dylib.1.3.11
Missing link target: /Applications/Xcode.app/Contents/Developer/Platforms/iPhoneSimulator.platform/Developer/SDKs/iPhoneSimulator6.1.sdk/System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/OSServices.framework/Headers->Versions/Current/Headers
Missing link target: /Applications/Xcode.app/Contents/Developer/Platforms/iPhoneSimulator.platform/Developer/SDKs/iPhoneSimulator6.1.sdk/System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/WebServicesCore.framework/Headers->Versions/Current/Headers
Missing link target: /Applications/Xcode.app/Contents/Developer/Platforms/iPhoneSimulator.platform/Developer/SDKs/iPhoneSimulator6.1.sdk/usr/include/c++/4.2.1/4.2.1->4.2.1
Missing link target: /Library/Frameworks/AEProfiling.framework->../../Applications/Motion.app/Contents/Frameworks/AEProfiling.framework
Missing link target: /Users/hans/Library/Containers/com.apple.ShareKitHelper/Data/Documents/iChats->../../../../../Documents/iChats
Missing link target: /Users/hans/Library/Containers/com.apple.ShareKitHelper/Data/Library/Application Scripts/com.apple.ShareKitHelper->../../../../../Application Scripts/com.apple.ShareKitHelper
Missing link target: /Users/hans/Library/Containers/com.apple.ShareKitHelper/Data/Library/ColorSync->../../../../ColorSync
Missing link target: /usr/share/java/Tools/Java VisualVM.app/Contents/Resources/VisualVM.icns->/System/Library/Java/Support/VisualVM.bundle/Contents/Resources/VisualVM.icns
* Install HomeBrew (does not require sudo)
<no new busted links>
* Install system updates
1 new busted link:
> Missing link target: /System/Library/StagedFrameworks/Safari/WebKit.framework/Frameworks->Versions/Current/Frameworks
* Install some HomeBrew packages, (go, fishfish, tree, git, mercurial)
< no new busted links>
* Install dozens of apps via App Store
< no new busted links>
* Install dozen more apps via App Store
< no new busted links>
* Configure settings via System Preferences (turn on photo stream, among other things), install font "SourceCodePro", customize terminal.app, configure prompt to show git status
New busted links:
> Missing link target: /Users/hans/Library/Containers/com.apple.ImageKit.RecentPictureService/Data/Documents/iChats->../../../../../Documents/iChats
> Missing link target: /Users/hans/Library/Containers/com.apple.ImageKit.RecentPictureService/Data/Library/Application Scripts/com.apple.ImageKit.RecentPictureService->../../../../../Application Scripts/com.apple.ImageKit.RecentPictureService
> Missing link target: /Users/hans/Library/Containers/com.apple.ImageKit.RecentPictureService/Data/Library/ColorSync->../../../../ColorSync
> Missing link target: /Users/hans/Library/Containers/com.apple.photostream-agent/Data/Documents/iChats->../../../../../Documents/iChats
> Missing link target: /Users/hans/Library/Containers/com.apple.photostream-agent/Data/Library/Application Scripts/com.apple.photostream-agent->../../../../../Application Scripts/com.apple.photostream-agent
> Missing link target: /Users/hans/Library/Containers/com.apple.photostream-agent/Data/Library/ColorSync->../../../../ColorSync