I think I've figured out what is causing the graphical glitches on my end. I've gone the entire week *without* issue and my application usage consisted of primarily Apple branded apps: Xcode, Mail, Calendar --no issues at all.
Then today, I was using TEXT Wrangler to edit a script and when I woke the mac from sleep, BAM! the corrupted screen refresh showed itself. I'm almost sure that these non-retina optimized apps are causing the issue.
This all makes me think there is a bug in the way OS X scales non-retina apps. Perhaps when that piece of code in OS X is executed, it corrupts something in the graphics buffer or something... One thing I have noticed, is the apps that have been having issue are ones that OS X has to scale everything, even the window title... I have no idea what the technical difference is, but I notice that some apps use retina-friendly cocoa controls and only some things are scaled, and others seem to have everything scaled (ie: Microsoft Word)... It's the latter type that seem to be causing all of my issues.
Can anyone shed any light?