Yup, I'm having the same problem, except that my machine keeps crashing over and over again. I've gone through the console, and it seems like different processes keep crashing (crash reporter, MDS (Spotlight), kernel_task, etc.) I can safely boot into Safe Mode, but if I restart my machine, almost as soon as I get past the login screen, I get screen glitches and the machine either restarts itself or hangs. NOT HAPPY.
MBP Retina 2.7 GHz, 16 GB RAM, 512 GB hard drive. I installed all of the latest software updates (Thunderbolt, MBP Retina update, MBP mid-2012 OS X version, etc.)
I transferred over all files and apps from my mid-2011 MBP overnight. I thought it was some incompatibility with installed software on my old machine (from which I'm typing this), so I started uninstalling things as soon as I could get logged in. Little Snitch, gone. EyeTV, gone. SMCFanControl, gone. Going through the Console, I saw that an old ATI program was trying to launch, so I pulled that and all of its associated .kext files out. Nothing worked. So, I'm reinstalling Lion on that machine right now, and we'll see how it goes.
I've spent my entire morning working on this *&(%^ thing. I am NOT pleased. I don't have time to be a beta tester for Apple.