OK I have read every post in this thread.
I use my Mac heavily all day in PS and LR and never had an issue at all. I was, however, using a Wacom tablet exclusively.
When I replaced my work machine with a new iMac I took the old (reliable) mini (2012) home.
I use it at home with a mouse. Not a tablet.
I immediately started losing the cursor. At first I thought it was the funky old MS mouse I was using but nooo, the brand new wireless magic mouse exhibited the same behavior.
The cursor can disappear almost at any time but usually (for me) disappears when the machine is idle for some time. I do switch resolutions from a connected big screen TV on occasion but even when mirroring is off and the resoltion is set properly for the display the problem occurs.
I never lose the cursor on my new iMac when using the tablet. I can't say I would if I used a mouse but the fact is that the phenomena has ONLY appeared when I have connected a mouse (wireless or corded) to the machine.