Latest Mac Mini, wired Apple Keyboard, Wireless trackpad, OSX 10.8.1.
had zero disappearances until I ran Lion Designer 3.3.
Command-tab sort of works... the mouse cursor appears in the other app, but come back to this one (Chrome) and it's gone again.
The only reliable way I have found to get the cursor back (for a little bit) is two-finger tap (Secondary Click)
Almost never use Launchpad or Mission Control.
Curious, I just tried Launchpad after discovering that moving my cursor all the way right (where my Dock is) will make the cursor re-appear. Anyway, in Launchpad, the cursor is unpredicatable. first time it wasn't there at all (except on the dock), second time it was there, then went poof.
So very bizarre.