I am also experiencing problems with my Microsoft mouse. I think we are now running in a fundamental issue: Apple persists in providing UI with smallish items (too small fonts impossible to scale up without decreasing display resolution, too small buttons and UI controls, etc.) while mouse resolution constantly increases to accomodate gamers. And that's even not a gamer mouse I have; this is the simple Comfort mouse! This makes UI almost unusable: you click and the pointer slides away from the smallish target, you try to move the mouse and away it goes, etc. No builtin mouse settings allow to work around. You have to purchase third-party software and try MANY of them to get something that somewhat works but is far from satisfactory. With Decelarate, I got mouse acceleration (that was making the pointer move very fast and jump from places to places on the screen) turned off, but the mouse move is very slow and requires several moves of the hand to get from one edge of the screen to the other. And the scroll wheel is WAY too fast, jumping pages around. It will be easier to use the scroll bars, which is VERY annoying, because they are too small to focus the mouse pointer on them! And back/forward buttons just don't work! Tilting the wheel scrolls horizontally, yes, but EXTREMELY slowly. So I would have to try USB Overdrive, Steermouse, ControllerMate, etc. All of them will give me promising results, I will come to purchase one of them, then some time later, it will become flawky and forum posts will orient me to one of the others! This is what I read in forum posts: somebody having problems with Overdrive and being proposed to try Steermouse or ControllerMate. I don't want to pay 100$ just to get my mouse working!!!
So yes, mouse support on Mac OS X Mountain Lion is very bad. My impression is that the HID builtin driver is VERY BASIC and bare, and there is a dedicated driver for the trackpad. But it is BAD, VERY BAD! That makes MacBook Pro almost the only usable target, with the builtin screen, not an external monitor! How about a Mac Mini with a USB mouse plugged in? With a UI constantly requiring the mouse, with smallish fonts requiring constant zooming in and out, this makes the platform almost unusable for me. The best thing I can do is to start a terminal and write commands there. But doing this, I am better off with Ubuntu, which in addition makes my mouse happy! I am very disappointed and would like to understand HOW people are able to use this OS. As a computer scientist, I find extremely frustrating that an OS is beyond me and would require me to turn away.