Iphone 5 sometimes touch screen unresponsive

I took off my case, but the screen was still very slow to respond. I have a 5c that I just purchased and I downloaded the latest fix to iOS 8 just 2 days ago. Should I take off the case when charging? Take the phone back to the store?

Try removing the case. If it does not help, try charging the phone using a different power source. If the problem persists the apple store should help you out.

I read replies here until I got bored. I never found a solution. I couldn't shut off my iphone 5 to reboot. All the case and powersupply advice is worthless. Finally got lucky by holding the home button and the power button depressed simultaneously for a long time. It rebooted and is working ok for now. I am running iOS 8.3

Well i didn't get bored and read through the replies. Since nothing helped, I also tried what you suggested and it made things *worse*. After reboot, I couldn't even swipe to unlock until maybe 50 tries. Then the thing really freaked me out, opening apps all by itself. It OPENED THE MESSAGE app and started typing random characters. I'm sure it would have sent them too, but at least the home button still worked. This is on the first day of a refurbished 5s with iOS 9.x something. Crazy stuff for sure! This thing is going back tomorrow.

I also experienced problems in terms of the screen not responding to touch.

After a reboot (holding both the sleep and home buttons down for 10sec) it boots up working, but then later the touch screen does not respond.

The issue was resolved for me when I Restored the iPhone software, nothing else fixed it.

Make sure you have a few hours free, and you know all your logins for your Apple account, email accounts and apps... because this will wipe the phone and you will have to then add all your login details, email accounts and apps (you can select which apps you want to add back on via iTunes).

So when you are ready connect the phone to your computer, select the phone in iTunes, back-up to icloud or your computer. Then choose restore. Then setup the phone as a 'new phone' rather than migrating the data back onto it. Its a tedious process but the phone is running fast now, so worthwhile.

Actually I have had similar problems after migrating to new Apple computers - and having to start with a clean sheet and move stuff over individually, I think after a while things get in a tangle - so best to start a fresh!

Tabasshum