Hey Drew,
So I've posted a few questions and responses and maybe I spoke too soon. The 'fix' Focusrite support had me try actually didn't work, though it appeared it had. Basically I'm still getting the issue, but I have found the exact sequence to replicate it every time. If I connect the Saffire by FW, start it up, then the macbook pro after having use the macbook's built-in audio (for anything), I get no sound output. It seems like if I restart the mac a couple ( I think at least twice), the Saffire is recognised and I can get audio out through it. So once it IS working, I tested it by shutting the Saffire down, disconnecting and using anything, ie. iTunes through the built-in output which automatically activates. Now, I shut down the mac. I connect the FW, start the Saffire, then the macbook and as predicted no output through the Saffire. I remembered you saying something in this thread about messing with the Sample Rate setting in MixControl (3.1). So I opened it up, flipped it from 48 to 44.1 and viola!, the output through the Saffire is working. I can repeat this experiment over and over. My question to you is, when you ran the DiceTool fix, did it show 0 ins/outs before you proceded to update the firmware? I still show all the ins/outs. It seems like you had the same issue as I do now, and the DiceTool fixed it. Possibly mine is slightly different. The Focusrite tech seemed to think my issue was different, but like I said the fix we went through didn't work. I'm thinking there is an issue with MixControl 3.1 an dmy slightly older MAcBook Pro (Mid-2009, OSX 10.6.8 Snow Leopard). Not sure. Any help from anyone would be greatly appreciated.
Wyatt