In my opinion, there are several degrees to which you can take the SSD plus Data_Drive optimization.
1) Buy a Big SSD and don't move anything. Manually redirect only your Big Photos, Music, and Movies files on a different Data drive. This approach is really easy, but requires a very large and expensive SSD. I think this is sloppy and I do not recommend it.
2) Use the existing "How to move the Home Foilder" methods often referenced here to move Users home directories, one-by-one, off the SSD to a Data drive. No Terminal commands are required for this solution. I think this is not hard to implement, requires no Terminal commands, and is the solution I recommend all SSD Users adopt.
3) use #2 above, plus create a new "Admin-only" User, use it ONLY for Administration, and Do NOT move it to the data drive. This allows the SSD to stand alone (it still has that Admin-only User you can use to log in) if the Data drive gets in trouble and won't mount. Highly recommended.
4) use #3 above, and add: Move selected ~/Library files, such as Preferences or Caches (or Both), back to the SSD. This may require the use of Terminal commands to set up the required Links. In my opinion, this is more complicated, and an embellishment that adds complexity many Users may not want, in exchange for a speedup that is difficult to quantify. I suggest this improvement may be for Users who are developers, or think like developers.
Alternative with no Terminal SymLinks, but a little complicated:
In Server/WorkStation setup where ALL files are stored on the Server, Caches stored in the Users home folder on the Server have been an ongoing annoying performance issue. Many solutions for Folder Redirection of the ~/Library/Caches folder have been developed over the years, and Apple finally added a "canned" one in 10.5 and later.
There are some tools in the Server Administration Tools (Workgroup Manager) that can accommodate automatic "Folder Redirection" of the ~/Library/Caches folder to another location at login, such as /tmp/yourname/Library/Caches/ by default. These CAN be used on a "regular" Mac. These do not require the use of Terminal, but when used on a single Mac require you to run the version of Workgroup Manager appropriate for your version of Mac OS X, directly on the Mac. More info in a follow-on posting.
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In Conclusion:
there are a number of increasingly complex ways to set up your SSD plus Data_Drive. Choose one that matches your abilities -- choosing something that is too complicated will make it difficult for you to maintain, and that can be a real problem.