On Adobe forum, the part in quote italics, some things will always go to the system boot drive even after changing preferences to try to use another disk drive volume.
And none of the existing drives are good candidates for Adobe's cache and scratch.
Scratch: A volume that is only for temporary cached files and which is erased between projects. A separate dedicated partition or disk drive.
So having both a 240GB boot drive, and one or two more SSDs for cache / scratch that I have been trying to "sell the idea" is still something needed to add to resolve this.
The ideal is to use PCIe Sonnet card and a couple of SSDs. 500GB for $299 is a fantastically good price and performance for such purpose. Coupled with the $150 (non RAID, and RAID might be a new "topic" of what why and how) or the better higher performance Pro card for $300. Difference of 500MB/sec vs 900MB/sec.
The SSD RAID makes the system and Adobe run smoother, no delays, and makes up for having less than 24-32GB RAM.
The amount of cache and scratch used is proportional to just how large and number of layers and the type of image files being manipulated.
Which is why the who topic of optimizing performance is detailed. Of course throwing as much RAM at the task and other things helps. So some people use a pair (2) Sonnet Tempo Pro cards and 4 x 500GB SSDs. That plus an Nvidia GTX 570 with 2.5GB video memory or more helps as well and uses CUDA.
Graphic cards have a lot of computing power and when programs are written to take advantage of them, as parts of CS6 is.
Of course some are shooting weddings or professionally and time is money and they want the best quality and don't want to be held back by their computer struggling to do what they ask of it. Some are hobbyists and can afford to wait and put up with some delay.
CS6 can be slow to write to disk. That is another place where putting your projects on a RAID helps. Moving your project to an SSD array, the same as your scratch array, is the fastest location and then you need to SAVE while you work to another location.
Having the system on 120GB SSD made things faster and smoother. The changes that could be made would take the problems and bottlenecks out.
An SSD doing all that IO, all those writes of IO, is a concern. TRIM and keep a couple good current backups. Find and create a 150GB partition to clone the system to. Then boot from the clone with TRIM Enabler and use Disk Utility to REPAIR and invoke TRIM on the SSD.
That also insures that your clone of your system works, is bootable, as intended, and you can rely on CCC for backup of the system.
250GB Samsung 840 $170
http://www.amazon.com/Samsung-Series-120GB-internal-MZ-7TD120BW/dp/B009NHAF06/
Sonnet Tempo (non-Pro) $118 for a single SSD or two in non-RAID
http://www.amazon.com/Sonnet-Technologies-Tempo-Drives-TSATA6-SSD-E2/dp/B0096P62 G6/
Those pair of products for the array would help. Two SSDs making 500GB scratch and I would even replace the 120GB being used now for the system and keep it as a spare system backup or to save money use it for scratch and use a new 240GB for system until you can buy another 250GB SSD. But $300 to get started with and have a disk location to be used for cache and Adobe scratch.