This has started to show up on my MBP 6.1 (15-inch, Mid 2010), which contains an NVIDIA GeForce GT 330M 256 MB discrete GFX and an Intel HD Graphics integrated GFX. I have tried to narrow it down, but it seems rather pointless, because I cannot reliably trigger it. One thing that helps in my case is the use of gfxCardStatus v2.3. Whenever the smearing shows up (mostly by a third-party programm not calling the integrated/discrete switching properly, I suppose), I select "discrete only" for a while and the problem vanishes.
I have many possible culprits, among which for example are tools like Parallels, Office for Mac 2011 (especially Word and Outlook seem to be causing unmotivated irregular discrete/integrated GFX switches), Bitcasa, Safari plugins (especially any Adobe plugin, like flash), and others.
This problem never occurred on 10.6.x, or 10.8.x (which I ran on my MPB). It is very unlikely a hardware issue, and neither PRAM nor SMC resetting really helps. I believe we should start to collect suspicious concole log entries with regard to GFX to pinpoint the problem. For example (probably not related):
"Error: this application, or a library it uses, has passed an invalid numeric value (NaN, or not-a-number) to CoreGraphics API. This is a serious error and conributes to the overall degradation of system stability and reliability. ..."
This is the other thread to monitor regarding solutions: https://discussions.apple.com/thread/5493333