FWIW, I've managed to corrupt 3 different Drobo arrays by connecting them to a machine with 10.9.1...
Drobo gen.2 via firewire
Drobo Pro via iSCSI (and then via USB2 when iSCSI connectivity unexpicably failed - drobo RMA in process)
Drobo 5D via Thunderbolt (and via USB2)
Yes, I've been foolish enough to buy three Drobos over the years... I admit it.
My point, I don't think it's particular to any specific hardware transport layer... whatever the problem is, it's more general and wide-spread.
I've tried connecting these arrays back to a 2011 MBP running 10.8.5, and they're still completely flakey now. Drive Genius 3.2 says it's repaired the file system, but the drives mount and soon become inaccessible. Finder just spins until I navigate to another volume. Try too many things and the whole system locks up, presumably waiting for filesystem I/O from the array which never occurs.
Currently, my Drobo gen.2 is connected via firewire and appears mounted, but is non-functional and non-responsive. The array has even spun-down the disks and fan. Lights are green, but nobody's home.
Something is seriously wrong.
My primary array (5D), and two backups (Pro and gen.2) are all totally screwed now. over 50 TB of storage unusable from any computer.
Apple, Drobo... hello?