Use a tool such as OmniDiskSweeper (ODS) to explore your volume and find out what's taking up the space. You can also delete files with it, but don't do that unless you're sure that you know what you're deleting and that all data is safely backed up. That means you have multiple backups, not just one.
Deleting files inside an iPhoto or Aperture library will corrupt the library. Any changes to a photo library must be made from within the application that created it. The same goes for Mail files.
Proceed further only if the problem isn't solved by the above steps.
ODS can't see the whole filesystem when you run it just by double-clicking; it only sees files that you have permission to read. To see everything, you have to run it as root.
If you have more than one user account, make sure you're logged in as an administrator. The administrator account is the one that was created automatically when you first set up the computer.
Install ODS in the Applications folder as usual. Quit it if it's running.
Triple-click anywhere in the line of text below on this page to select it, then copy the selected text to the Clipboard by pressing the key combination command-C:
sudo /Applications/OmniDiskSweeper.app/Contents/MacOS/OmniDiskSweeper
Launch the built-in Terminal application in any of the following ways:
☞ Enter the first few letters of its name into a Spotlight search. Select it in the results (it should be at the top.)
☞ In the Finder, select Go ▹ Utilities from the menu bar, or press the key combination shift-command-U. The application is in the folder that opens.
☞ Open LaunchPad. Click Utilities, then Terminal in the icon grid.
Paste into the Terminal window (command-V). You'll be prompted for your login password, which won't be displayed when you type it. You may get a one-time warning to be careful. If you see a message that your username "is not in the sudoers file," then you're not logged in as an administrator.
The application window will open, eventually showing all files in all folders, sorted by size with the largest at the top. It may take a few minutes for ODS to finish scanning your files.
I don't recommend that you make a habit of doing this. Don't delete anything while running ODS as root. If something needs to be deleted, make sure you know what it is and how it got there, and then delete it by other, safer, means. When in doubt, leave it alone or ask for guidance.
When you're done with ODS, quit it and also quit Terminal.
