spinning beach ball with every click
I've got a 3.5 year old Mac Mini 2.3 GHz Core i5 with 4 GB of RAM running OS X 10.9.2. A couple months ago, at no specific moment in time, my mini started to slow down, it's continued to get slower and slower to the point now where every time I click on anything, I get a spinning beach ball for as many as 10 - 20 seconds before the Mac processes what I've done. I have run permission repairs and also bought and installed CleanMyMac2, while it "cleaned" 50+ GB of junk, my Mac's behavior has not changed. Anyone got any other ideas?
Mac mini, OS X Mavericks (10.9.2), 4 GB RAM 2.3 GHz Intel Core i5