I've got similar problems. It started with installing Yosemite (non-dev release) on my MBP 17" (late 2011 = 8,3). The actual installation went quick and without complaints, but then the problems began.
None of my mainly used apps worked correctly: Mail, Safari, Firefox, VMware Fusion, 1Password, iCloud etc. pp. I also couldn't edit my own documents. Inspecting permissions in Finder showed that ACLs were kind of weird, showing my account twice. In Terminal, files had permissions rw–-–-rw- (read-write for me and for everyone, no permissions for group). As stated here, repairing permissions does not help anything inside users' home directories.
I was able to drill it down to my Login keychain which was reported to be read-only (?!?) — and empty. I understand that this was a main cause of problems like not being able to start iCloud services and entailing a slew of further effects. It got better when I set my home dir's permissions correctly and applied them recursively to all my files (all using Finder). I also restored the login.keychain from Time Machine. This helped a bit, since then I was at least able to use the system without constantly being nagged by error messages.
I also changed my account to have admin rights as advised here.
Restoring Firefox and Safari worked also by restoring files in ~/Library/… using Time Machine.
Repairing Mail was more complicated, after trying to let Mail upgrade itself from the files already in my Library (getting stuck every time) I restored the Library/Mail folder from TM, disabled all Mail accounts via System Preferences and one by one re-activated them. Now it seems as everything is working again.
Repairing VMware Fusion was the hardest part so far. Since my main VM has 250 GB, it is not included in TM. It turned out that one snapshot's configuration file (*.vmdk) had zero length. I copied a different snapshot's vmdk and modified it accordingly. After some fiddling I got the VM to work again — phew!
So, basically I can work again, after repairing the system from Friday till Monday (Thanks Apple for this wasted weekend!). But every now and then, errors keep popping up. For example, today Safari again lost its stored tabs. Understandably, my confidence in my work machine dwindled away.
Especially looking into Console logs shows that there is still a bunch of things in disorder:
UserEventAgent[19]: Failed to remove /.MobileBackups.trash, error: Error Domain=NSCocoaErrorDomain Code=513 "“.MobileBackups.trash” couldn’t be removed because you don’t have permission to access it."
kernel[0]: BUG in process suhelperd[238]: over-released legacy external boost assertions (0 total, 0 external, 0 legacy-external)
kernel[0]: Sandbox: mdworker(8258) deny file-read-data /Users/xy/Library/Preferences/com.apple.security.revocation.plist
pboard[8420]: Attempt to unlink previous shared memory during startup returned an error. Continuing...
ocspd[136]: Error opening OCSP cache (100022)
kernel[0]: Sandbox: appleeventsd(28) deny file-read-metadata /Library
mdworker[8683]: code validation failed in the process of getting signing information: Error Domain=NSOSStatusErrorDomain Code=-67062 "The operation couldn’t be completed. (OSStatus error -67062.)"
com.apple.xpc.launchd[1]: (com.apple.photostream-agent[8835]) LaunchServices returned a bundle URL that does not match with the LoginItem's known association.
com.apple.xpc.launchd[1]: (com.apple.photostream-agent) Service only ran for 0 seconds. Pushing respawn out by 10 seconds.
I only picked some messages I consider relevant; some of them are logged by the hundreds, filling up the log files. I also suspect there are problems with sandboxing.
Any hints what to do? Re-install? Hope for 10.10.1? Consult a Genius?